Pusat Sains Negara or National Science Centre is a science centre in Kuala Lumpur, Malaysia. Perched atop a hill on 8 hectares of landscaped grounds at Bukit Kiara on the northwestern fringes of the city, the centre was officially opened on 29 November 1996 by former Prime Minister Tun Dr Mahathir bin Mohamad.

The main aim of the science centre is to promote greater understanding and interest in science and technology. The building resembles a truncated cone capped with a geodesic dome. Among the themes featured in the exhibition galleries are an environmental odyssey, pathways to discovery, future world and thinking machines.